CVE-2025-12921: A vulnerability has been found in OpenClinica Community Edition up to 3.12.2/3.13

Routine

MEDIUM 4.3DOWNGRADE

CVE-2025-12921 is a medium-severity flaw (CVSS 4.3) affecting openclinica. Below: why it ranks where it does, which versions are affected, what to do, and the exact commands.

A vulnerability has been found in OpenClinica Community Edition up to 3.12.2/3.13. Affected by this issue is some unknown functionality of the file /ImportCRFData?action=confirm of the component CRF Data Import. Such manipulation of the argument xml_file leads to xml injection. It is possible to launch the attack remotely. The exploit has been disclosed to the public and may be used. The vendor was contacted early about this disclosure but did no

Why this priority

Public exploit reference

No fix is published yet: follow the downgrade or mitigation steps.

Risk facts

CVSS score	4.3 (Medium)
Attack vector	Network (remote)
Attack complexity	Low
Privileges needed	Low
User interaction	None
EPSS exploit chance	0.6% (top 53%)
CISA exploited list	No
Weakness	CWE-74, CWE-91
Published	2025-11-10
Last modified	2026-10-07

Publisher (CNA): VulDB · Vendor: openclinica

Last updated 2026-10-07 · Sources: CVE Program, NVD, CISA KEV, EPSS and vendor advisories · How we score

Am I affected?

Timeline

2025-11-10 00:15 UTCPublished CVE record published
2026-10-07 21:10 UTCUpdated Record last modified

openclinica openclinica DOWNGRADE

Affected: 3.12.2 · 3.13

Fixed in: no fixed release known

Safe to downgrade to: a release before 3.12.2

1. Check installed version

apt-cache policy openclinica || rpm -q openclinica || openclinica --version

2. No fixed release: DOWNGRADE to a release before 3.12.2 (Debian / Ubuntu)

apt-cache madison openclinica sudo apt install openclinica=<VERSION_BEFORE_3.12.2> sudo apt-mark hold openclinica

2. No fixed release: DOWNGRADE (RHEL / Amazon Linux / Fedora)

dnf --showduplicates list openclinica sudo dnf downgrade openclinica-<VERSION_BEFORE_3.12.2> sudo dnf versionlock add openclinica

Downgrade risk

Downgrading can break dependent software and may reopen older bugs. Read the distro advisory first and test on a non-production host.

After downgrade

Restart the service, and keep the package held until a fixed release ships.

Verify at the official source NVD · CVE Program · Report a problem with this page
Scores and fixes here are computed automatically from those and other public sources. Confirm with the vendor advisory before changing production systems.

Quick answers

How do I fix CVE-2025-12921?

openclinica: downgrade or apply the listed mitigation. Exact commands for each OS are on this page.

Is CVE-2025-12921 being exploited?

CVE-2025-12921 is not on the CISA Known Exploited Vulnerabilities list at the time of the last update. Check again, as this can change.

What does CVE-2025-12921 affect?

CVE-2025-12921 affects openclinica. Severity is medium (CVSS 4.3). A vulnerability has been found in OpenClinica Community Edition up to 3.12.2/3.13. Affected by this issue is some unknown functionality of the file /ImportCRFData?action=confirm of the component CRF Data Import. Such manipulation of the arg

How urgent is CVE-2025-12921?

Priority 32/100. Public exploit reference

Related CVEs

CVE-2025-12922 MEDIUM 6.3 DOWNGRADE A vulnerability was found in OpenClinica Community Edition up to 3.12.2/3.13

References

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