CVE-2026-21997: Vulnerability in the Oracle Life Sciences Empirica Signal product of Oracle Life Science Applications (compone

Routine

HIGH 8.5UPGRADE

CVE-2026-21997 is a high-severity flaw (CVSS 8.5) affecting life sciences empirica signal. Below: why it ranks where it does, which versions are affected, what to do, and the exact commands.

Vulnerability in the Oracle Life Sciences Empirica Signal product of Oracle Life Science Applications (component: Common Core). Supported versions that are affected are 9.2.1-9.2.3. Easily exploitable vulnerability allows low privileged attacker with network access via HTTP to compromise Oracle Life Sciences Empirica Signal. While the vulnerability is in Oracle Life Sciences Empirica Signal, attacks may significantly impact additional products

Why this priority

High severity

A fixed release or distro patch exists.

Risk facts

CVSS score	8.5 (High)
Attack vector	Network (remote)
Attack complexity	Low
Privileges needed	Low
User interaction	None
EPSS exploit chance	0.2% (top 90%)
CISA exploited list	No
Weakness	CWE-284
Published	2026-04-21
Last modified	2026-10-26

Publisher (CNA): Oracle · Vendor: oracle

Last updated 2026-10-26 · Sources: CVE Program, NVD, CISA KEV, EPSS and vendor advisories · How we score

Am I affected?

Timeline

2026-04-21 21:16 UTCPublished CVE record published
2026-10-26 21:10 UTCUpdated Record last modified

oracle life sciences empirica signal UPGRADE

Affected: >= 9.2.1 and <= 9.2.3

Fixed in: newer than 9.2.3

Safe to downgrade to: a release before 9.2.1

1. Check installed version

apt-cache policy life-sciences-empirica-signal || rpm -q life-sciences-empirica-signal || life-sciences-empirica-signal --version

2. UPGRADE to newer than 9.2.3 (Debian / Ubuntu)

sudo apt update && sudo apt install --only-upgrade life-sciences-empirica-signal

2. UPGRADE (RHEL / Amazon Linux / Fedora)

sudo dnf upgrade life-sciences-empirica-signal

Note

Distros often backport fixes without changing the version number. Confirm with the distro advisory or changelog.

3. If no update is available yet, DOWNGRADE to a release before 9.2.1 (Debian / Ubuntu)

apt-cache madison life-sciences-empirica-signal sudo apt install life-sciences-empirica-signal=<VERSION_BEFORE_9.2.1> sudo apt-mark hold life-sciences-empirica-signal

3. If no update is available yet, DOWNGRADE (RHEL / Amazon Linux / Fedora)

dnf --showduplicates list life-sciences-empirica-signal sudo dnf downgrade life-sciences-empirica-signal-<VERSION_BEFORE_9.2.1> sudo dnf versionlock add life-sciences-empirica-signal

Downgrade risk

Downgrading can break dependent software and may reopen older bugs. Read the distro advisory first and test on a non-production host.

After downgrade

Restart the service, and keep the package held until a fixed release ships.

Verify at the official source NVD · CVE Program · Report a problem with this page
Scores and fixes here are computed automatically from those and other public sources. Confirm with the vendor advisory before changing production systems.

Quick answers

How do I fix CVE-2026-21997?

life sciences empirica signal: upgrade to newer than 9.2.3. Exact commands for each OS are on this page.

Is CVE-2026-21997 being exploited?

CVE-2026-21997 is not on the CISA Known Exploited Vulnerabilities list at the time of the last update. Check again, as this can change.

What does CVE-2026-21997 affect?

CVE-2026-21997 affects life sciences empirica signal. Severity is high (CVSS 8.5). Vulnerability in the Oracle Life Sciences Empirica Signal product of Oracle Life Science Applications (component: Common Core). Supported versions that are affected are 9.2.1-9.2.3. Easily exploitable vulnerability allows low privileged at

How urgent is CVE-2026-21997?

Priority 32/100. High severity

References

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